Zope is a beautifully integrated set of solutions to common web development problems. It works in a substantially different way to traditionally scripted web-applications. Think of it as a collection of objects help with web publishing rather than a set of scripts to do a job.
I have personally tried to use Zope on two separate occasions, but I just couldn’t get past the voodoo of it all. If you’re coming from a “standard” scripting background, be prepared to leave everything you know at the door.
If you read through the comments, Zope seems to come out on the short end of the stick. Many more complaints than endorsements. There was also a link to FreeZope, which will give you a free Zope site to work with and try it out. If you do, post back here with your experience.